Adipocyte Determination- and Differentiation-dependent Factor 1/Sterol Regulatory Element-binding Protein 1c Regulates Mouse Adiponectin Expression
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چکیده
منابع مشابه
Regulation of Peroxisome Proliferator-Activated Receptor g Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism
1999, 19(8):5495. Mol. Cell. Biol. Michael Briggs, Bruce M. Spiegelman and Johan Auwerx Fruchart, Kim, Jamila Najib, Genevieve Martin, Jean-Charles Lluis Fajas, Kristina Schoonjans, Laurent Gelman, Jae B. and Metabolism Implications for Adipocyte Differentiation Regulatory Element Binding Protein 1: and Determination Factor 1/Sterol Expression by Adipocyte Differentiation γ Proliferator-Activat...
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Fatty acid synthase (FAS), a nutritionally regulated lipogenic enzyme, is transcriptionally controlled by ADD1/SREBP1c (adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c), through insulin-mediated stimulation of ADD1/SREBP1c expression. Progesterone exerts lipogenic effects on adipocytes, and FAS is highly induced in breast tumor cell lines upon progeste...
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We have previously shown that angiotensin II (Ang II) increases the expression of the gene encoding adipocyte fatty acid synthase (FAS). Here we investigate the mechanism responsible for increased FAS gene transcription by Ang II. We demonstrate that Ang II increased luciferase activity by 3-fold in 3T3-L1 adipocytes transfected with fusion constructs linking the FAS promoter to the luciferase ...
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We show that Id (inhibitor of DNA binding) 2 and Id3, dominant negative members of the helix-loop-helix (HLH) family, interact with the adipocyte determination and differentiation factor 1 (ADD1)/sterol regulatory element-binding protein (SREBP) 1c, a transcription factor of the basic HLH-leucine zipper family that controls the expression of several key genes of adipose metabolism. Gel mobility...
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Insulin resistance, a state of reduced responsiveness to insulin, is associated with obesity and is the major pathogenic indicator of metabolic syndrome. Although major advances have been made in unraveling the underlying defects that cause insulin resistance, many of the pathways and regulators that connect insulin to its downstream metabolic effects are not completely understood. Epidemiologi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m400238200